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“In professional guidelines, several classes of medications are equally recommended as first-line therapies. ARBs block receptors in the blood vessels that angiotensin attaches to, diminishing its vessel-constricting effect. ACE inhibitors lower blood pressure by blocking an enzyme early in the system so that less angiotensin, a chemical that narrows blood vessels, is produced, and blood vessels can remain wider and more relaxed. The findings are based on an analysis of eight electronic health record and insurance claim databases in the United States, Germany and South Korea that include almost 3 million patients taking a high blood pressure medication for the first time with no history of heart disease or stroke.īoth types of medicines work on the renin-angiotensin-aldosterone system, a group of related hormones that act together to regulate blood pressure.
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Currently, ACE inhibitors are prescribed more commonly than ARBs as a first-time blood pressure control medicine. While the class of blood pressure-lowering medicines called angiotensin-converting enzyme (ACE) inhibitors may be prescribed more commonly, angiotensin receptor blockers (ARBs) work just as well and may cause fewer side effects. ET Monday, July 26, 2021ĭALLAS, JPeople who are just beginning treatment for high blood pressure can benefit equally from two different classes of medicine – angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) – yet ARBs may be less likely to cause medication side effects, according to an analysis of real-world data published today in Hypertension, an American Heart Association journal.
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